Leading economic development programs are administered through the following organizations: The City of San Mateo Economic Development & Business Assistance Division (various business attraction & retention activities), the San Mateo Area Chamber of Commerce (b-to-b, policy advocacy, regional marketing), the Downtown San Mateo Association (Downtown marketing & promotions)
Additionally, the city's San Mateo Main Public Library offers a "Job Seekers." program with volunteers to help job seekers search and prepare for employment. The City of San Mateo is working closely with the Downtown San Mateo Association to assist in its efforts to create a PBID (property-based improvement district) for the Downtown. The PBID would allow for an enhanced level of service and capital improvement budget for the Downtown district.